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1.
Acta cir. bras ; 28(1): 33-38, jan. 2013. ilus, tab
Article in English | LILACS | ID: lil-662345

ABSTRACT

PURPOSE: To assess the effects of unripe Musa sapientum peel on the healing of surgical wounds in rats. METHODS: One hundred and twenty Wistar rats were divided into two treatment groups of 60 animals each: the control group (gel without the active ingredient) and experimental group (4% Musa sapientum peel gel). A 4 x 4 cm surgical wound was created on the back of each animal. The wound was cleaned daily with 0.9% saline, treated with 4% gel or natrosol gel (control), and covered with gauze. Animals from both groups were sacrificed after seven, 14 and 21 days of treatment; the tissue from the wound site was removed together with a margin of normal skin for histological analysis. RESULTS: No significant differences in wound contraction rates (p=0.982) were found between time points (seven, 14 and 21 days of treatment) in both groups. However, a significantly higher wound contraction rate was observed in the control group on day 21 compared with the experimental group (p=0.029). There were no significant differences in histomorphological features between groups. The experimental group showed an increased number of polymorphonuclear cells on day 7, with a significant reduction on day 21 (p=0.026). CONCLUSION: The use of 4% unripe Musa sapientum peel gel on surgical wounds in rats resulted in an increased number of polymorphonuclear cells on day 7, reduced wound contraction, reduced vascular proliferation and increased concentration of collagen fibers on day 21.


Subject(s)
Animals , Male , Rats , Gels/therapeutic use , Musa , Phytotherapy , Plant Extracts/therapeutic use , Wound Healing/drug effects , Biopsy , Collagen/analysis , Random Allocation , Rats, Wistar , Reproducibility of Results , Time Factors , Treatment Outcome
2.
Acta cir. bras ; 26(5): 379-382, Sept.-Oct. 2011. ilus, tab
Article in English | LILACS | ID: lil-599640

ABSTRACT

PURPOSE: To determine the optimum concentration of a gel obtained from unripe banana (Musa sapientum) peel for wound treatment in rats. METHODS: A randomized triple blind study was conducted with 40 Wistar rats, which were divided into 4 groups: CG, control group; G2 percent, 2 percent gel concentration group; G4 percent, 4 percent gel concentration group; and G10 percent, 10 percent gel concentration group. The banana peel gel was applied daily, for 7 days, to a 4-cm² wound created on the back of each animal of all groups. After this period, the wounds were biopsied. Statistical analysis was carried out using the Kruskal-Wallis test complemented by the Student-Newman-Keuls test. RESULTS: Macroscopic examination revealed that partial epithelialization occurred in all groups. Wound contraction was also observed in all groups and ranged from 1.38 to 1.57 mm in the study groups, and from 1.03 to 1.10 mm in the control group, with significant differences (p < 0.05) between the groups: CG and G10 percent, G2 percent and G4 percent, G2 percent and G10 percent. The interquartile deviation was smaller between the groups CG and G4 percent. CONCLUSION: The 4 percent gel obtained from unripe banana peel (G4 percent) resulted in better epithelialization of wounds healed by secondary intention compared with other gel concentrations.


OBJETIVO: Avaliar a concentração ideal do gel da casca de Musa sapientum verde no tratamento de feridas em ratos. MÉTODOS: Estudo randomizado, triplo cego, com 40 ratos da linhagem Wistar divididos em quatro grupos: GC controle, G2 por cento gel a 2 por cento, G4 por cento gel a 4 por cento, G10 por cento gel a 10 por cento. Realizou-se aplicação diária do gel nas diferentes concentrações, durante sete dias, em uma ferida de 4 cm² realizada no dorso de cada rato. Após este período, as lesões foram biopsiadas. Para analise dos dados utilizou-se o teste de Kruskal-Wallis complementado pelo teste de Student-Newman-Keuls. RESULTADOS: Os achados macroscópicos demonstraram reepitelização parcial em todos os grupos. A contração da área da ferida variou entre 1,38 a 1,57 mm nos grupos de estudo, e entre 1,03 a 1,10 mm no grupo controle. Houve diferença significante (p < 0,05) entre os grupos: GC e G10 por cento, G2 por cento e G4 por cento, G2 por cento e G10 por cento, sendo o desvio interquartílico menor entre os grupos GC e G4 por cento. CONCLUSÃO: O gel a 4 por cento da casca de M. sapientum verde promoveu maior área de epitelização em feridas com cicatrização por segunda intenção, em relação ao gel nas outras concentrações testadas.


Subject(s)
Animals , Rats , Musa , Phytotherapy/methods , Plant Extracts/administration & dosage , Wound Healing/drug effects , Wounds and Injuries/drug therapy , Biopsy , Dose-Response Relationship, Drug , Gels/administration & dosage , Random Allocation , Rats, Wistar , Treatment Outcome
3.
Acta ortop. bras ; 15(4): 227-230, 2007. ilus, tab
Article in Portuguese | LILACS | ID: lil-465812

ABSTRACT

OBJETIVO: Avaliar a influência da hipertrofia mamária sobre as dores na coluna e o quanto poderão comprometer as atividades habituais das pacientes. MÉTODOS: Realizou-se estudo transversal analítico em pacientes dos ambulatórios de Ortopedia e Cirurgia Plástica do Hospital Universitário Samuel Libânio, Pouso Alegre - MG. Foram examinadas 100 mulheres, 50 com hipertrofia mamária (grupo estudo) e 50 com mamas normais (grupo controle). O tamanho das mamas foi classificado conforme critérios de Sacchini.. A Escala Numeral Analógica (NRS) e o questionário de Roland-Morris foram utilizados para avaliar a intensidade das dores na coluna e as limitações resultantes destes sintomas. Realizado teste estatístico comparando os grupos em relação as variáveis analisadas. RESULTADOS: A média da idade das pacientes do grupo estudo e controle foram de 32,2 anos e de 32,7 anos respectivamente, e o IMC foi maior no grupo estudo. Os escores do NRS e do Roland-Morris foram maiores no grupo de estudo em relação ao grupo controle com significância estatística. CONCLUSÃO: Os resultados obtidos mostraram que as dores nas costas são mais intensas e determinaram maior limitação das atividades habituais em pacientes portadoras de hipertrofia mamária.


OBJECTIVE: To evaluate the influence of breast hypertrophy on the incidence of back pain and how much they can interfere in patients' daily activities. METHODS: This was a cross-sectional analytic study in patients examined at the Outpatient Orthopedics and Plastic Surgery Departments at Samuel Libânio University Hospital in Pouso Alegre, MG. 100 women were examined, 50 presenting breast hypertrophy (study group) and 50 with normal breast size (control group). Breasts were classified according to Sacchini's criteria. The Numerical Rating Scale (NRS) and the Roland-Morris questionnaire were used in order to evaluate the magnitude of back pain and the limitations arising from these symptoms. RESULTS: The mean age of the patients in the study group was 32.2 years and 32.7 for the control group. The scores in the NRS scale and Roland- Morris Questionnaire were higher in the study group when compared to the control group. CONCLUSION: The results achieved showed that back pain is more severe and determined more extensive limitations in the daily activities for patients presenting breast hypertrophy.


Subject(s)
Humans , Female , Adolescent , Adult , Middle Aged , Back Pain , Breast , Cross-Sectional Studies , Neck Pain , Pain Measurement , Quality of Life , Hypertrophy
4.
Rev. bras. mastologia ; 11(4): 127-131, dez. 2001. ilus
Article in Portuguese | LILACS | ID: lil-311292

ABSTRACT

Estudamos o uso do retalho toracoaxilar na reparação tardia da quadrantectomia súperoðlateral, associada à mastoplastia contralateral, demonstrando os resultados e o seguimento pósðoperatório, entre maio de 1998 e dezembro de 2000. Nossa casuística foi composta por 8 pacientes que apresentavam seqüelas de quadrantectomia súperoðlateral associada à assimetria da mama contralateral. O seguimento pósðoperatório variou entre 8 e 43 meses, com média de 25,5 meses. O retalho foi viável em 100 por cento dos casos, e todas as 8 paciente (100 por cento) fizeram autoðavaliação dos resultados estéticos, classificandoðos como excelentes. A equipe médica avaliou os resultados como bons. O retalho mostrouðse viável e de fácil realização, com resultados estéticos satisfatórios, expandindo as possibilidades de reparação tardia nas quadrantectomias súperoðlaterais


Subject(s)
Humans , Female , Breast Neoplasms , Follow-Up Studies , Mammaplasty , Mastectomy, Segmental , Plastic Surgery Procedures , Surgical Flaps
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